丹曲林(Dantrolene)
丹曲林(Dantrolene)
商品名(trade name)
|
|
药理作用(Pharmacological Effects)
|
*muscle relaxant that acts by abolishing excitation-contraction coupling in muscle cells, probably by action on the ryanodine receptor
*inhibit RYR of Excitation-Contraction Coupling, and cause calcium ion cannot release. RYR is on Sarcoplasmic reticulum:详细说明当动作电位到达肌细胞时,会造成T小管上的DHPR与SR上的RYR发生构型上的变化,使得钙离子从肌浆质网释出,造成肌肉收缩。而Dantrlene则会与骨骼肌上的RYR1结合(非平滑肌RYR2或心肌,具选择性),让钙离子释放减少造成骨骼肌的舒张。 参见:兴奋收缩联合作用(Excitation-Contraction Coupling, EC coupling) 资料来源:farmacol |
用量与用法(Dosage and Usage)
|
]per os is common, from low dose to high dose 25mg~100mg/day. This drug can be use bid or qid
]IV infusion ]IV bolus |
适应症(Indications)
|
{恶性高温临床症状(clinical signs of malignant hyperthermia):同时施打全身麻醉剂(halothane)与骨骼肌松弛剂(SCh)后,会造成SR上的钙离子通道持续开启,使肌肉过度收缩
参见:痉挛(spasticity) |
副作用(Side effect)
|
}some CNS infection
}Lethargic }dizziness }weakness }liver disease |
禁忌/交互作用(Contraindications / interaction)
|
|
▼神经传导(Nerve conduction)
显示/隐藏(show/hide)
显示/隐藏(show/hide)
▼肌肉简介(muscle introduction)
显示/隐藏(show/hide)
显示/隐藏(show/hide)