＊muscle relaxant that acts by abolishing excitation-contraction coupling in muscle cells, probably by action on the ryanodine receptor
＊inhibit RYR of Excitation-Contraction Coupling, and cause calcium ion cannot release. RYR is on Sarcoplasmic reticulum：详细说明当动作电位到达肌细胞时，会造成T小管上的DHPR与SR上的RYR发生构型上的变化，使得钙离子从肌浆质网释出，造成肌肉收缩。而Dantrlene则会与骨骼肌上的RYR1结合（非平滑肌RYR2或心肌，具选择性），让钙离子释放减少造成骨骼肌的舒张。
参见：兴奋收缩联合作用(Excitation-Contraction Coupling, EC coupling)

资料来源：farmacol

]per os is common, from low dose to high dose 25mg~100mg/day. This drug can be use bid or qid
]IV infusion
]IV bolus

{恶性高温临床症状(clinical signs of malignant hyperthermia)：同时施打全身麻醉剂（halothane）与骨骼肌松弛剂（SCh）后，会造成SR上的钙离子通道持续开启，使肌肉过度收缩
参见：痉挛(spasticity)

}some CNS infection
}Lethargic
}dizziness
}weakness
}liver disease

禁忌/交互作用(Contraindications / interaction)